Glutathione deficiency-elicited reprogramming of hepatic metabolism protects against alcohol-induced steatosis

Depletion of glutathione (GSH) is considered a critical pathogenic event promoting alcohol-induced lipotoxicity. We recently show that systemic GSH deficiency in mice harboring a global disruption of the glutamate-cysteine ligase modifier subunit (Gclm) gene confers protection against alcohol-induce...

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Bibliografiska uppgifter
I publikationen:Free Radic Biol Med
Huvudupphovsmän: Chen, Ying, Manna, Soumen K., Golla, Srujana, Krausz, Kristopher W., Cai, Yan, Garcia-Milian, Rolando, Chakraborty, Tanushree, Chakraborty, Joyeeta, Chatterjee, Raghunath, Thompson, David C., Gonzalez, Frank J., Vasillou, Vasilis
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848780/
https://ncbi.nlm.nih.gov/pubmed/31351176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.07.025
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