RDNA-12. THE FANCONI ANAEMIA (FA) PATHWAY AND GLIOBLASTOMA: A NEW FOUNDATION FOR DNA DAMAGE RESPONSE TARGETED COMBINATIONS

Treatment resistance in glioblastoma is underpinned by highly interconnected DNA damage response (DDR) processes. The FA-pathway is a fundamental DDR process required for the resolution of replication fork impeding lesions, and we have previously shown that it is inactive in normal brain, but is re-...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Rominiyi, Ola, Myers, Katie, Gomez-Roman, Natividad, Lad, Nikita, Dar, Dawoud, Jellinek, David, Chalmers, Anthony, Carroll, Thomas, Chen, Beining, Al-Tamimi, Yahia, Collis, Spencer
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Radiation Biology and DNA Repair
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847875/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.871
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