ATIM-30. COMBATING RECURRENT GLIOBLASTOMA WITH MDNA55, AN INTERLEUKIN-4 RECEPTOR TARGETED IMMUNOTHERAPY, THROUGH MRI-GUIDED CONVECTIVE DELIVERY

MDNA55, an IL4R-directed toxin, is being studied in a Phase 2b trial in recurrent GBM (rGBM) patients at first or second relapse. MDNA55 is co-infused with Gadolinium-based contrast agent and delivered as a single intratumoral infusion using Convection Enhanced Delivery (CED). Primary endpoint is me...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Sampson, John, Singh Achrol, Achal, Aghi, Manish, Bankiewicz, Krystof, Brem, Steven, Brenner, Andrew, Butowski, Nicholas, Chandhasin, Chandtip, Chowdhary, Sajeel, Coello, Melissa, Floyd, John R, Kesari, Santosh, Merchant, Fahar, Merchant, Nina, Randazzo, Dina, Vogelbaum, Michael, Vrionis, Frank, Zabek, Miroslaw, Bexon, Martin
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Adult Clinical Trials–Immunologic
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847825/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.029
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