ATIM-30. COMBATING RECURRENT GLIOBLASTOMA WITH MDNA55, AN INTERLEUKIN-4 RECEPTOR TARGETED IMMUNOTHERAPY, THROUGH MRI-GUIDED CONVECTIVE DELIVERY

MDNA55, an IL4R-directed toxin, is being studied in a Phase 2b trial in recurrent GBM (rGBM) patients at first or second relapse. MDNA55 is co-infused with Gadolinium-based contrast agent and delivered as a single intratumoral infusion using Convection Enhanced Delivery (CED). Primary endpoint is me...

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發表在:Neuro Oncol
Main Authors: Sampson, John, Singh Achrol, Achal, Aghi, Manish, Bankiewicz, Krystof, Brem, Steven, Brenner, Andrew, Butowski, Nicholas, Chandhasin, Chandtip, Chowdhary, Sajeel, Coello, Melissa, Floyd, John R, Kesari, Santosh, Merchant, Fahar, Merchant, Nina, Randazzo, Dina, Vogelbaum, Michael, Vrionis, Frank, Zabek, Miroslaw, Bexon, Martin
格式: Artigo
語言:Inglês
出版: Oxford University Press 2019
主題:
Adult Clinical Trials–Immunologic
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847825/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.029
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