CBMT-25. THE KLF4(K409Q) MUTATION IN MENINGIOMA IMPAIRS HIF-1Α DEGRADATION AND CAN BE HARNESSED FOR TARGETED THERAPY

Recently, several Non-NF2 driver mutations (KLF4, TRAF7, SMO, AKT1(E17K)) in meningioma have been identified. While they have been shown to correlate with certain pathological subtypes and locations, the clinical impact and repercussions on cellular pathways have largely remained elusive. Through an...

詳細記述

保存先:
書誌詳細
出版年:Neuro Oncol
主要な著者: von Spreckelsen, Niklas, Waldt, Natalie, Poetschke, Rebecca, Kesseler, Christoph, Dohmen, Hildegard, Jiao, Hui-Ke, Nemeth, Attila, Deckert, Martina, Angenstein, Frank, Krischek, Boris, Stavrinou, Pantelis, Timmer, Marco, Remke, Marc, Kirches, Elmar, Goldbrunner, Roland, Chiocca, Ennio, Huettelmaier, Stefan, Acker, Till, Mawrin, Christian
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2019
主題:
Cell Biology and Metabolism
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847820/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.147
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