CBMT-25. THE KLF4(K409Q) MUTATION IN MENINGIOMA IMPAIRS HIF-1Α DEGRADATION AND CAN BE HARNESSED FOR TARGETED THERAPY

Recently, several Non-NF2 driver mutations (KLF4, TRAF7, SMO, AKT1(E17K)) in meningioma have been identified. While they have been shown to correlate with certain pathological subtypes and locations, the clinical impact and repercussions on cellular pathways have largely remained elusive. Through an...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: von Spreckelsen, Niklas, Waldt, Natalie, Poetschke, Rebecca, Kesseler, Christoph, Dohmen, Hildegard, Jiao, Hui-Ke, Nemeth, Attila, Deckert, Martina, Angenstein, Frank, Krischek, Boris, Stavrinou, Pantelis, Timmer, Marco, Remke, Marc, Kirches, Elmar, Goldbrunner, Roland, Chiocca, Ennio, Huettelmaier, Stefan, Acker, Till, Mawrin, Christian
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Cell Biology and Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847820/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.147
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