KLF4 K409Q –mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment

Abstract Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations in meningioma have been identified and correlated with certain pathological subtypes, locations and clinical observations. Alterations of cellular pathways due to these mutations, however...

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Detalhes bibliográficos
Main Authors: Niklas von Spreckelsen, Natalie Waldt, Rebecca Poetschke, Christoph Kesseler, Hildegard Dohmen, Hui-Ke Jiao, Attila Nemeth, Stefan Schob, Cordula Scherlach, Ibrahim Erol Sandalcioglu, Martina Deckert, Frank Angenstein, Boris Krischek, Pantelis Stavrinou, Marco Timmer, Marc Remke, Elmar Kirches, Roland Goldbrunner, E. Antonio Chiocca, Stefan Huettelmaier, Till Acker, Christian Mawrin
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-04-01
Colecção:Acta Neuropathologica Communications
Assuntos:
Meningioma
Mutation
K409Q
Hypoxia
HIF
Edema
Acesso em linha:http://link.springer.com/article/10.1186/s40478-020-00912-x
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