IMMU-38. CRISPR BASED GENOME EDITING OF HUMAN T CELLS TO TARGET H3.3K27M MUTATION IN GLIOMAS

We recently identified an HLA-A*02:01-restricted CD8 T cell epitope encompassing the H3.3K27M mutation, which is common in diffuse midline glioma, and a corresponding high-affinity T cell receptor (TCR) that recognizes the epitope. While recombinant viral vectors have been widely used for genetic re...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Hegde, Bindu, Roth, Theodore, Nguyen, David, Chheda, Zinal, Apathy, Ryan, Marson, Alex, Okada, Hideho
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847734/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.530
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