GENE-32. SYNTHETIC LETHAL INTERACTIONS WITH IDH1R132H IN GLIOMA STEM-LIKE CELLS

Gliomas are the most frequently diagnosed human primary brain tumors. Mutations in Isocitrate Dehydrogenase (IDH) 1 occur in the vast majority of low grade gliomas and secondary high grade glioblastomas. A single amino acid missense mutation in IDH1 at arginine 132 (R132H) is an early event in tumor...

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Vydáno v:Neuro Oncol
Hlavní autoři: Ventosa, Maria, Kadiyala, Padma, Carney, Stephen, Castro, Maria, Lowenstein, Pedro
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Genetics and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847725/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.434
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