GENE-60. THE EPITRANSCRIPTOMIC CODE IN LGG: METABOLICALLY REPROGRAMMED IDH-MUTANT GLIOMAS ALTER tRNA MODIFICATION LANDSCAPE

BACKGROUND: Diffuse lower grade gliomas (LGGs) are generally slow growing primary central nervous system tumors that occur in early adult life. The prevalence of isocitrate dehydrogenase (IDH) mutations is high in LGG, and induces excess production of the oncometabolite 2-hydroxyglutarate (2-HG). Th...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Scheepbouwer, Chantal, Borland, Kayla, Aparicio, Ernesto, Verschueren, Heleen, Wedekind, Laurine, Ramaker, Jip, Misovic, Branko, CM Kouwenhoven, Mathilde, Noske, David, Vandertop, Peter, Wesseling, Pieter, Wurdinger, Tom, Hackenberg, Michael, Kellner, Stefanie, Koppers-Lalic, Danijela
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Genetics and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847647/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.462
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