GENE-60. THE EPITRANSCRIPTOMIC CODE IN LGG: METABOLICALLY REPROGRAMMED IDH-MUTANT GLIOMAS ALTER tRNA MODIFICATION LANDSCAPE

BACKGROUND: Diffuse lower grade gliomas (LGGs) are generally slow growing primary central nervous system tumors that occur in early adult life. The prevalence of isocitrate dehydrogenase (IDH) mutations is high in LGG, and induces excess production of the oncometabolite 2-hydroxyglutarate (2-HG). Th...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuro Oncol
Prif Awduron: Scheepbouwer, Chantal, Borland, Kayla, Aparicio, Ernesto, Verschueren, Heleen, Wedekind, Laurine, Ramaker, Jip, Misovic, Branko, CM Kouwenhoven, Mathilde, Noske, David, Vandertop, Peter, Wesseling, Pieter, Wurdinger, Tom, Hackenberg, Michael, Kellner, Stefanie, Koppers-Lalic, Danijela
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2019
Pynciau:
Genetics and Epigenetics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847647/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.462
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