Star-PAP controlled alternative polyadenylation coupled poly(A) tail length regulates protein expression in hypertrophic heart

Alternative polyadenylation (APA)-mediated 3′-untranslated region (UTR) shortening is known to increase protein expression due to the loss of miRNA regulatory sites. Yet, mRNAs with longer 3′-UTR also show enhanced protein expression. Here, we identify a mechanism by which longer transcripts generat...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Sudheesh, A P, Mohan, Nimmy, Francis, Nimmy, Laishram, Rakesh S, Anderson, Richard A
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847588/
https://ncbi.nlm.nih.gov/pubmed/31598705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz875
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