PDTM-06. DISULFIRAM-COPPER PROLONGS SURVIVAL AND REDUCES STEM-CELLNESS IN PEDIATRIC GROUP 3 MEDULLOBLASTOMA THROUGH NUCLEAR SEQUESTRATION OF NPL4

Medulloblastoma (MB), an aggressive pediatric brain malignancy, is commonly classified into four subtypes. Although survival has improved remarkably, Group 3 and Shh-driven tumors still experience high rates of recurrent and metastatic disease. Disulfiram (DSF), a safe and inexpensive drug, has show...

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Publicat a:Neuro Oncol
Autors principals: Serra, Riccardo, Zhao, Tianna, Casaos, Joshua, Leviton Gorelick, Noah, Mangraviti, Antonella, Olivi, Alessandro, Brem, Henry, Jackson, Eric, Tyler, Betty
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Pediatric Tumors
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847474/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.782
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