PDTM-39. CRACKING THE HISTONE CODE: REVEALING THERAPEUTIC EPIGENETIC TARGETS THROUGH HISTONE H3 TAIL ANALYSIS OF DIFFUSE INTRINSIC PONTINE GLIOMA

INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) is a highly morbid pediatric cancer. Up to 80% harbor a Histone H3K27M mutation, which alters wild type Histone H3 protein post-translational modifications (PTMs) and genomic enrichment patterns to impact chromatin structure and transcription reg...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Li, Daphne, Huang, Tina, Camarillo, Jeannie, Qi, Jin, Weiss, Hannah, Nazarian, Javad, Thomas, Paul, Saratsis, Amanda
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Pediatric Tumors
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847470/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.815
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