ATIM-25. PD-1 INHIBITION CAN BE COMBINED WITH IL-12 IN SUBJECTS WITH RECURRENT GLIOBLASTOMA

Monotherapy with intratumoral Ad-RTS-hIL-12 (Ad), a novel gene therapeutic conditionally expressing IL-12 under the transcriptional control of oral veledimex (V, 20 mg) acting via the proprietary RheoSwitch Therapeutic System® (RTS®), was shown in a phase 1 Main study (NCT02026271) to elicit a susta...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Chiocca, Ennio, Lukas, Rimas, Rao, Ganesh, Buck, Jill, Demars, Nathan, Smith, Amy, Miao, John, Zhou, John, Gelb, Arnold, Cooper, Laurence
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Adult Clinical Trials–Immunologic
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847446/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.024
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