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ATIM-15. A PHASE 1 STUDY OF Ad-RTS-hIL-12 + VELEDIMEX IN ADULTS WITH RECURRENT GLIOBLASTOMA: DOSE DETERMINATION WITH UPDATED OVERALL SURVIVAL

Ad-RTS-hIL-12 (Ad) is a novel gene therapy expressing IL-12 via the RheoSwitch Therapeutic System(®) gene switch under control of an oral activator ligand, veledimex (V). We previously reported on an open label Phase I trial describing biological activity of recombinant IL-12 with downstream IFN-γ a...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Chiocca, E Antonio, Lukas, Rimas, Yu, John, Oberheim Bush, Nancy Ann, Buck, Jill, Demars, Nathan, Barrett, John, Gelb, Arnold, Wang, Yunxia, Cooper, Laurence, Lebel, Francois
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216124/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.010
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