PDCT-12. CLINICAL EFFICACY OF ONC201 IN THALAMIC H3 K27M-MUTANT GLIOMA

ONC201, the first bitopic DRD2 antagonist for clinical oncology, has shown efficacy in H3 K27M-mutant glioma. We performed an integrated preclinical and clinical analysis of ONC201 in thalamic H3 K27M-mutant glioma. ONC201 was effective in mouse intra-uterine electroporation (IUE)-generated H3 K27M-...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Rahman Kawakibi, Abed, Gardner, Sharon, Chi, Andrew, Kurz, Sylvia, Wen, Patrick, Arrillaga-Romany, Isabel, Batchelor, Tracy, Butowski, Nicholas, Sumrall, Ashley, Shonka, Nicole, Harrison, Rebecca, DeGroot, John, Mehta, Minesh, Odia, Yazmin, Hall, Matthew, Daghistani, Doured, Cloughesy, Timothy, Ellingson, Benjamin, Umemura, Yoshie, Schwartz, Jonathan, Yadav, Vivekanand, Cartaxo, Rodrigo, Miklja, Zachary, Bruzek, Amy, Siada, Ruby, Mullan, Brendan, Stallard, Stefanie, Muruganand, Ashwath, Wierzbicki, Kyle, Paul, Alyssa, Wolfe, Ian, Kumar-Sinha, Chandan, Marini, Bernard, Leonard, Marcia, Garton, Hugh, Mody, Rajen, Robertson, Patricia, Merdinger, Krystal, Tarapore, Rohinton, Oster, Wolfgang, Allen, Joshua, Koschmann, Carl
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Pediatric Clinical Trials
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847419/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.773
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