CSIG-04. PAN-RTK INHIBITION OF sLRIG1 MEDIATES AXL DOWNREGULATION IN GLIOBLASTOMA

INTRODUCTION: Aberrant regulation of receptor tyrosine kinase (RTK) activity is characteristic of Glioblastoma (GBM). However, RTK-based targeted therapies have been largely unsuccessful in GBM patients, partially due to the complexity and redundance of RTK signaling. LRIG1 (Leucine-rich Repeats and...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Neirinckx, Virginie, Hau, Ann-Christin, Schuster, Anne, Fritah, Sabrina, Chevigné, Andy, Schmidt, Mirko H, Niclou, Simone
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Cell Signaling and Signaling Pathways
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847328/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.175
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