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RDNA-03. AUTOPHAGY AS A NOVEL THERAPEUTIC TARGET IN MUTANT IDH1 GLIOMAS
Mutated Isocitrate dehydrogenase 1 (IDH1(R132H); mIDH1) is found in 50% of all adult gliomas and in 80% of lower-grade gliomas. IDH1(R132H) promotes 2-hydroxyglutarate production which inhibits histone and DNA demethylases, inducing epigenetic reprogramming of the tumor transcriptome. We recently de...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6847308/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.863 |
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