RDNA-03. AUTOPHAGY AS A NOVEL THERAPEUTIC TARGET IN MUTANT IDH1 GLIOMAS

Mutated Isocitrate dehydrogenase 1 (IDH1(R132H); mIDH1) is found in 50% of all adult gliomas and in 80% of lower-grade gliomas. IDH1(R132H) promotes 2-hydroxyglutarate production which inhibits histone and DNA demethylases, inducing epigenetic reprogramming of the tumor transcriptome. We recently de...

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Vydáno v:Neuro Oncol
Hlavní autoři: Nunez, Felipe, Garcia-Fabiani, Maria, Kadiyala, Padma, Hong, Hanna, Comba, Andrea, Lyssiotis, Costas, Cheng, Shi-Yuan, Lowenstein, Pedro, Castro, Maria
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Radiation Biology and DNA Repair
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847308/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.863
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