NIMG-36. EVALUATION OF [18F]DASA-23 FOR NON-INVASIVE MEASUREMENT OF ABERRANTLY EXPRESSED PYRUVATE KINASE M2 IN GLIOMA: FIRST-IN-HUMAN STUDY

OBJECTIVES: We developed 1-((2-fluoro-6-(fluoro-[18F])phenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine ([18F]DASA-23) as a novel radiopharmaceutical to measure pyruvate kinase M2 levels by positron emission tomography (PET). PKM2 catalyzes the final step in glycolysis, the key process of tum...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Patel, Chirag, Beinat, Corinne, Haywood, Tom, Murty, Surya, Xie, Yuanyang, Recht, Lawrence, Nagpal, Seema, Thomas, Reena, Khalighi, Mohammad, Gandhi, Harsh, Holley, Dawn, Gambhir, Sanjiv
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Neuro-Imaging
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847186/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.706
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