CSIG-06. DEPATUXIZUMAB MAFODOTIN (ABT-414)-INDUCED GLIOBLASTOMA CELL DEATH REQUIRES EGFR OVEREXPRESSION, BUT NOT PHOSPHORYLATION

Glioblastomas commonly (40%) exhibit epidermal growth factor receptor (EGFR) amplification, half of these tumors carry the EGFRvIII deletion variant characterized by an in-frame deletion of exons 2–7, resulting in constitutive EGFR activation. Although EGFR tyrosine kinase inhibitors had only modest...

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Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: von Achenbach, Caroline, Blot, Vincent, Weiss, William, Weller, Michael
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2019
Aiheet:
Cell Signaling and Signaling Pathways
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847073/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.177
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