CMET-14. BRAIN METASTASES: A NEW PATHOPHYSIOLOGY, A NEW TREATMENT PARADIGM, AND, PERHAPS, A NEW PROGNOSIS

INTRODUCTION: Brain metastases are widely held to reach the CNS through the blood stream. We provide evidence that the initial site of most CNS metastases is the CSF, with subsequent invasion of brain parenchyma. We also model the therapeutic implications of this novel hypothesis. METHODS: Two neuro...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Dowd, Richard, Ouyang, Tao, Thamburaj, Krishnamoorthy, Aregawi, Dawit, Safran, Howard, Zacharia, Brad, Glantz, Michael
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
CNS Metastasis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847066/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.215
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