CMET-14. BRAIN METASTASES: A NEW PATHOPHYSIOLOGY, A NEW TREATMENT PARADIGM, AND, PERHAPS, A NEW PROGNOSIS

INTRODUCTION: Brain metastases are widely held to reach the CNS through the blood stream. We provide evidence that the initial site of most CNS metastases is the CSF, with subsequent invasion of brain parenchyma. We also model the therapeutic implications of this novel hypothesis. METHODS: Two neuro...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuro Oncol
Prif Awduron: Dowd, Richard, Ouyang, Tao, Thamburaj, Krishnamoorthy, Aregawi, Dawit, Safran, Howard, Zacharia, Brad, Glantz, Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2019
Pynciau:
CNS Metastasis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847066/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.215
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