IMMU-05. DISRUPTION OF THE CCR2 CHEMOKINE RECEPTOR PATHWAY OVERCOMES THERAPEUTIC RESISTANCE TO PD-1 BLOCKADE IN MALIGNANT GLIOMA

INTRODUCTION: Large scale clinical trials have failed to determine efficacy of adjuvant PD-1 blockade in recurrent glioblastoma (GBM). However, recent phase 2 clinical trial results demonstrating the potential of neo-adjuvant anti-PD-1 treatment have renewed enthusiasm for the use of immune checkpoi...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Flores-Toro, Joseph, Luo, Defang, Campbell, James, Charo, Israel, Singh, Rajinder, Schall, Thomas, Datta, Meenal, Jain, Rakesh, Mitchell, Duane, Harrison, Jeffrey
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847050/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.499
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