CBMT-09. THERAPEUTIC EFFECT OF INDUCTION OF POLYGLUTAMYLATION IN HIGH-DOSE METHOTREXATE THERAPY TO PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA

BACKGROUND: Polyglutamylation is a reversible protein modification with a high occurrence rate in tumor cells. Methotrexate (MTX) incorporated into cells is polyglutamylated and strongly binds to dihydrofolate reductase without competitive inhibition by leucovorin (LV). Tumor cells with high polyglu...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Fujimoto, Kenji, Shinojima, Naoki, Makino, Keishi, Ichimura, Koichi, Mukasa, Akitake
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Cell Biology and Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847040/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.131
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