IMMU-21. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION

Heterogeneous expression of target antigens allows tumor escape from chimeric antigen receptor-transduced T-cell (CART) therapy targeting a single antigen. While epidermal growth factor receptor (EGFR)vIII represents a glioblastoma (GBM)-specific antigen, its expression is heterogeneous within the t...

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Foilsithe in:Neuro Oncol
Main Authors: Watchmaker, Payal, Choe, Joseph, Carrera, Diego, Gilbert, Ryan, Yu, Wei, Downey, Kira, Roybal, Kole, Lim, Wendell, Okada, Hideho
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2019
Ábhair:
Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847014/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.514
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