PATH-48. THE DNA METHYLATION LANDSCAPE OF CORE AND PERIPHERAL DIFFUSE GLIOMA REGIONS SHOWS LITTLE SPATIAL SUBTYPE HETEROGENEITY AFTER CONSIDERING TUMOR PURITY

While diffuse gliomas are notorious for their histopathological, genetic and transcriptional spatial heterogeneity, little is known about their epigenetic spatial heterogeneity. The result of spatial (epi)genetic analysis is strongly influenced by the proportion of cancer cells in a sample, so calle...

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Vydáno v:Neuro Oncol
Hlavní autoři: Verburg, Niels, Barthel, Floris, Anderson, Kevin, Koopman, Thomas, Yaqub, Maqsood, Hoekstra, Otto, Lammertsma, Adriaan, Barkhof, Frederik, Pouwels, Petra, C Reijneveld, Jaap, Heijmans, Jan, Rozemuller, Annemieke, Costello, Joseph, Taylor, Michael, Vandertop, William, Boellaard, Ronald, Johnson, Kevin C, Wesseling, Pieter, de Witt Hamer, Philip, Verhaak, Roel
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Molecular Pathology and Classification - Adult and Pediatric
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847013/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.644
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