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Quantifying the impact of small molecule ligands on G-quadruplex stability against Bloom helicase
G-quadruplex (GQ) stabilizing small molecule (SM) ligands have been used to stabilize human telomeric GQ (hGQ) to inhibit telomerase activity, or non-telomeric GQs to manipulate gene expression at transcription or translation level. GQs are known to inhibit DNA replication unless destabilized by hel...
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| Publicado en: | Nucleic Acids Res |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6847008/ https://ncbi.nlm.nih.gov/pubmed/31544934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz803 |
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