RBTT-12. A PHASE I STUDY OF EGFRVIII-DIRECTED CAR T CELLS COMBINED WITH PD-1 INHIBITION IN PATIENTS WITH NEWLY, DIAGNOSED, MGMT-UNMETHYLATED GLIOBLASTOMA: TRIAL IN PROGRESS

BACKGROUND: This study builds on the results of the University of Pennsylvania sponsored phase I study of a single peripheral infusion of chimeric antigen receptor (CAR) T cells targeting epidermal growth factor receptor variant III (EGFRvIII) in recurrent glioblastoma (GBM) (NCT02209376). A dose of...

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Библиографические подробности
Опубликовано в: :Neuro Oncol
Главные авторы: Bagley, Stephen, Desai, Arati, Binder, Zev, Nasrallah, MacLean, Hwang, Wei-Ting, Maloney-Wilensky, Eileen, Prior, Timothy, Brem, Steven, O’Rourke, Donald
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
Предметы:
Randomized Brain Tumor Trials in Development
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846993/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.923
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