ATIM-15. SUSTAINED COMPLETE RADIOGRAPHIC RESPONSE AND PROLONGED SYSTEMIC IMMUNE ACTIVATION IN A PATIENT WITH MGMT UNMETHYLATED MIDLINE GLIOBLASTOMA RECEIVING CMV pp65-LAMP RNA-PULSED DENDRITIC CELL VACCINES

BACKGROUND: We initiated a Phase 2, randomized, placebo-controlled, clinical trial evaluating the efficacy of autologous CMV pp65-LAMP RNA pulsed dendritic cell vaccines mixed with GM-CSF and administered during cycles of adjuvant dose-intensified temozolomide (ATTAC II, NCT02465268). STUDY OBJECTIV...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Rahman, Maryam, Ghiaseddin, Ashley, Yegorov, Oleg, Yang, Changlin, Dechkovskaia, Anjelika, Tran, David, Massini, Tara, Kresak, Jesse, Mitchell, Duane
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Adult Clinical Trials–Immunologic
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846973/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.015
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