TMIC-35. IDH1 MUTATION IN GLIOMA REPROGRAMS EARLY MYELOID DIFFERENTIATION IN THE BONE MARROW (BM) TO PRODUCE NON-IMUNESUPPRESSIVE NEUTROPHILS

Gliomas are the most common primary brain tumors; patients exhibit a poor prognosis. Mutations in isocitrate dehydrogenase (mIDH) are present in most patients with lower grade glioma (LGG), and are correlated with better prognosis and survival. We postulated that mIDH1 induces epigenetic reprogrammi...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Alghamri, Mahmoud, Castro, Maria, Lowenstein, Pedro, Kamran, Neha, Kadiyala, Padma, Avvari, Ruthvik, Zhang, Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Tumor Microenvironment
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846775/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1069
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