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TMIC-20. ELIMINATION OF SENESCENT ASTROCYTES IN THE BRAIN TUMOR MICROENVIRONMENT ATTENUATES GLIOBLASTOMA RECURRENCE AFTER RADIOTHERAPY

Glioblastomas (GBM) are treated with high doses of ionizing radiation (IR) yet these tumors inevitably recur, and the recurrent tumors are highly therapy resistant. During GBM therapy, the surrounding brain tissue is irradiated along with the tumor. IR induces senescence in multiple cell types, and...

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Publicado en:Neuro Oncol
Main Authors: Fletcher-Sananikone, Eliot, Mukherjee, Bipasha, Burma, Sandeep
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846542/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1054
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