TMOD-03. SOMATIC MUTATIONS OF CHROMATIN REGULATOR Kmt2d IN CEREBELLAR PRECURSORS INFLUENCES SHH-MEDULLOBLASTOMA TUMORIGENESIS

Medulloblastoma (MB), the most common malignant pediatric brain tumor, is a classic example of dysregulation of developmental pathways leading to tumorogenesis. Despite advancements in multi-modal therapies, most patients suffer from long-term neurocognitive and neuroendocrine disabilities. The Soni...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Sanghrajka, Reeti, Tan, I-li, Wojcinski, Alexandre, Rallapalli, Harikrishna, Turnbull, Daniel, Ge, Kai, Joyner, Alexandra
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Tumor Models
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846525/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1102
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