TMIC-49. ABROGATING CD70 EXPRESSION IN GBM RESULTS IN A REDUCED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT

BACKGROUND: We found that CD70, as an immune modulator, in GBM plays a critical role in immunosuppression and tumor progression. Although CD70+ tumors recruit more CD3+ T cells than CD70(—) tumors do in patients with GBM, CD70 on GBM is also found to be involved in promoting CD8+ T cell death. The e...

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Vydáno v:Neuro Oncol
Hlavní autoři: Tao, Haipeng, Jin, Linchun, Mendez-Gomez, Hector, Long, Yu, Na, Meng, Hou, Alicia, Karachi, Aida, Lin, Zhiguo, Deleyrolle, Loic, Sayour, Elias, Mitchell, Duane, Huang, Jianping
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Tumor Microenvironment
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846444/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1083
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