SCIDOT-39. K16ApoE ENHANCES Aβ-ASSOCIATED 11C-PiB DEPOSITION AND PET SIGNAL IN APP/PS1 TRANSGENIC MICE

OBJECTIVE: The K16ApoE peptide enhances delivery of multiple agents across the blood-brain barrier (BBB). Transgenic mouse models are central to elucidating the underlying pathophysiology of Alzheimer’s Disease (AD) and provide a system for evaluating novel therapeutic strategies. PET imaging plays...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Brown, Desmond, Sarkar, Gobinda, Decklever, Teresa, Curran, Geoffry, Sarkar, Ameet, Schmeichel, Ann, Swaminathan, Suresh, Kandimala, Karunya, Jenkins, Robert, Burns, Terry, Lowe, Val
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
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Abstracts from the 3rd Sno-Scidot Joint Conference on Therapeutic Delivery to the CNS
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6845991/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1175
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