SCIDOT-28. TARGETED NANOPARTICLES FOR IMPROVED DRUG DELIVERY TO MEDULLOBLASTOMA

Platinum-based agents remain a key component of therapy for children with medulloblastoma, despite significant systemic side effects and only modest blood-brain barrier (BBB) penetration. Cisplatin has a cerebrospinal fluid-to-plasma ratio <5% and dose-limiting side effects of nephrotoxicity, oto...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Straehla, Joelle P, Boehnke, Natalie, Dacoba, Tamara G, Hammond, Paula T
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Abstracts from the 3rd Sno-Scidot Joint Conference on Therapeutic Delivery to the CNS
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846858/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1164
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