TMIC-44. IL-1 ANTAGONIST ANAKINRA INHIBITS GLIOBLASTOMA PROLIFERATION BY ANTAGONIZING THE PROINFLAMMATORY MICROENVIRONMENT

INTRODUCTION: The recombinant IL-1 receptor antagonist anakinra prevents binding of IL-1 to its receptor and blocks IL-1β-mediated proinflammatory signaling. It is currently used in the treatment of autoinflammatory diseases. As inflammation is a major driver of malignancy, we hypothesized that anak...

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發表在:Neuro Oncol
Main Authors: Effinger, David, Hübner, Max, Wu, Tingting, Thon, Niklas, Kreth, Friedrich-Wilhelm, Kreth, Simone
格式: Artigo
語言:Inglês
出版: Oxford University Press 2019
主題:
Tumor Microenvironment
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6845630/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1078
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