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MTOR PROMOTES BBB BREAKDOWN IN A MODEL OF ALZHEIMER’S DISEASE

Cerebral amyloid angiopathy (CAA) is characterized by fibrillar amyloid β (Aβ) association with cerebrovasculature, which leads to impaired brain vascular function, and is present in 87% of people with Alzheimer’s disease (AD). We previously showed that inhibition of mTOR by rapamycin prevented BBB...

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Detalhes bibliográficos
Publicado no:Innov Aging
Main Authors: Hernandez, Stephen F, Skike, Candice E Van, DeRosa, Nick, Galvan, Veronica
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6845248/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igz038.957
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