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Verapamil Ameliorates Motor Neuron Degeneration and Improves Lifespan in the SOD1(G93A) Mouse Model of ALS by Enhancing Autophagic Flux

Amyotrophic lateral sclerosis (ALS) is a progressive, paralytic disorder caused by selective degeneration of motor neurons in the brain and spinal cord. Our previous studies indicated that abnormal protein aggregation and dysfunctional autophagic flux might contribute to the disease pathogenesis. In...

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Библиографические подробности
Опубликовано в: :Aging Dis
Главные авторы: Zhang, Xiaojie, Chen, Sheng, Lu, Kaili, Wang, Feng, Deng, Jiangshan, Xu, Zhouwei, Wang, Xiuzhe, Zhou, Qinming, Le, Weidong, Zhao, Yuwu
Формат: Artigo
Язык:Inglês
Опубликовано: JKL International LLC 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844595/
https://ncbi.nlm.nih.gov/pubmed/31788329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2019.0228
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