Verapamil Ameliorates Motor Neuron Degeneration and Improves Lifespan in the SOD1(G93A) Mouse Model of ALS by Enhancing Autophagic Flux

Amyotrophic lateral sclerosis (ALS) is a progressive, paralytic disorder caused by selective degeneration of motor neurons in the brain and spinal cord. Our previous studies indicated that abnormal protein aggregation and dysfunctional autophagic flux might contribute to the disease pathogenesis. In...

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Detalhes bibliográficos
Publicado no:Aging Dis
Principais autores: Zhang, Xiaojie, Chen, Sheng, Lu, Kaili, Wang, Feng, Deng, Jiangshan, Xu, Zhouwei, Wang, Xiuzhe, Zhou, Qinming, Le, Weidong, Zhao, Yuwu
Formato: Artigo
Idioma:Inglês
Publicado em: JKL International LLC 2019
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Orginal Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844595/
https://ncbi.nlm.nih.gov/pubmed/31788329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2019.0228
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