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Toward the role of cholesterol and cholesterol transfer protein in autophagosome biogenesis
A forward chemical genetic approach led to identification of autogramins as novel autophagy inhibitors. Autogramins selectively target the cholesterol transfer protein GRAMD1A (GRAM domain containing 1A). Autogramins compete with cholesterol binding to the StART domain of GRAMD1A, thereby inhibiting...
Enregistré dans:
| Publié dans: | Autophagy |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Taylor & Francis
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6844521/ https://ncbi.nlm.nih.gov/pubmed/31512558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1666595 |
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