The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis

BACKGROUND & AIMS: Originally believed to be primarily a disorder of T-cell signaling, evidence shows that macrophage-lineage cells also contribute to the pathogenesis of Crohn’s disease (CD). Colony stimulating factor-1 (CSF-1) is a key regulator of the macrophage lineage, but its role in CD ha...

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Udgivet i:PLoS One
Main Authors: Manthey, Carl L., Moore, Beverley A., Chen, Yanqing, Loza, Matthew J., Yao, Xiang, Liu, Hao, Belkowski, Stanley M., Raymond-Parks, Holly, Dunford, Paul J., Leon, Francisco, Towne, Jennifer E., Plevy, Scott E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844469/
https://ncbi.nlm.nih.gov/pubmed/31710624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0223918
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