Effect of promoter, promoter mutation and enhancer on transgene expression mediated by episomal vectors in transfected HEK293, Chang liver and primary cells

The episomal vector cannot integrate into the host cell chromosome, which has no potential risk in gene therapy. However, the low level of transgene expression driven by episomal vectors needs to be solved. In this study, we investigated the effects of enhancers, promoters and promoter variants on t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Bioengineered
Hauptverfasser: Xu, Zhong-Jie, Jia, Yan-Long, Wang, Meng, Yi, Dan-Dan, Zhang, Wei-Li, Wang, Xiao-Yin, Zhang, Jun-He
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844389/
https://ncbi.nlm.nih.gov/pubmed/31668126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21655979.2019.1684863
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