A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer

BACKGROUND: A phase 1/2a dose escalation study of APC-100 (2,2,5,7,8-Pentamethyl-6-chromanol) was conducted to determine maximum tolerated dose (MTD), recommended phase 2 dose, toxicities and efficacy in men with castrate-resistant prostate cancer (CRPC). METHODS: This open label phase 1/2a study ut...

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Pubblicato in:Invest New Drugs
Autori principali: Kyriakopoulos, Christos E., Heath, Elisabeth I., Eickhoff, Jens C., Kolesar, Jill, Yayehyirad, Mulusew, Moll, Thomas, Wilding, George, Liu, Glenn
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844069/
https://ncbi.nlm.nih.gov/pubmed/26924129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-016-0334-y
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