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The Novel Direct Modulatory Effects of Perampanel, an Antagonist of AMPA Receptors, on Voltage-Gated Sodium and M-type Potassium Currents

Perampanel (PER) is a selective blocker of AMPA receptors showing efficacy in treating various epileptic disorders including brain tumor-related epilepsy and also potential in treating motor neuron disease. However, besides its inhibition of AMPA-induced currents, whether PER has any other direct io...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Lai, Ming-Chi, Tzeng, Ray-Chang, Huang, Chin-Wei, Wu, Sheng-Nan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6843791/
https://ncbi.nlm.nih.gov/pubmed/31652643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9100638
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