Variability in Loss of Multiple Enzyme Activities Due to the Human Genetic Variation P284T Located in the Flexible Hinge Region of NADPH Cytochrome P450 Oxidoreductase

Cytochromes P450 located in the endoplasmic reticulum require NADPH cytochrome P450 oxidoreductase (POR) for their catalytic activities. Mutations in POR cause multiple disorders in humans related to the biosynthesis of steroid hormones and also affect drug-metabolizing cytochrome P450 activities. E...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Parween, Shaheena, Rojas Velazquez, Maria Natalia, Udhane, Sameer S., Kagawa, Norio, Pandey, Amit V.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6843080/
https://ncbi.nlm.nih.gov/pubmed/31749697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01187
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