Variability in Loss of Multiple Enzyme Activities Due to the Human Genetic Variation P284T Located in the Flexible Hinge Region of NADPH Cytochrome P450 Oxidoreductase

Cytochromes P450 located in the endoplasmic reticulum require NADPH cytochrome P450 oxidoreductase (POR) for their catalytic activities. Mutations in POR cause multiple disorders in humans related to the biosynthesis of steroid hormones and also affect drug-metabolizing cytochrome P450 activities. E...

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書目詳細資料
發表在:Front Pharmacol
Main Authors: Parween, Shaheena, Rojas Velazquez, Maria Natalia, Udhane, Sameer S., Kagawa, Norio, Pandey, Amit V.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2019
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6843080/
https://ncbi.nlm.nih.gov/pubmed/31749697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01187
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