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Naphthoquinone Tryptophan Hybrids: A Promising Small Molecule Scaffold for Mitigating Aggregation of Amyloidogenic Proteins and Peptides

A current challenge faced by researchers is the lack of disease-modifying therapeutics for amyloid formation that is associated with several human diseases. Although the monomeric proteins or peptides involved in various amyloidogenic diseases do not have amino acid sequence homology, there appears...

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Bibliografske podrobnosti
izdano v:Front Cell Dev Biol
Main Authors: Viswanathan, Guru KrishnaKumar, Paul, Ashim, Gazit, Ehud, Segal, Daniel
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6843079/
https://ncbi.nlm.nih.gov/pubmed/31750300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2019.00242
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