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Targeted renal knockdown of Na(+)/H(+) exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila

Nephrolithiasis is one of the most common kidney diseases, with poorly understood pathophysiology, but experimental study has been hindered by lack of experimentally tractable models. Drosophila melanogaster is a useful model organism for renal diseases because of genetic and functional similarities...

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Publicat a:Am J Physiol Renal Physiol
Autors principals: Ghimire, Saurav, Terhzaz, Selim, Cabrero, Pablo, Romero, Michael F., Davies, Shireen A., Dow, Julian A. T.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6843049/
https://ncbi.nlm.nih.gov/pubmed/31364377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00551.2018
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