Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation: involvement of NF-κB, NLRP3, and gut microbiota

The sodium-dependent multivitamin transporter (SMVT; SLC5A6) is involved in intestinal absorption of vitamin B7 (biotin). We have previously shown that mice with an embryonic intestinal-specific SMVT knockout (KO) develop biotin deficiency and severe spontaneous intestinal inflammation in addition t...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Sabui, Subrata, Skupsky, Jonathan, Kapadia, Rubina, Cogburn, Kyle, Lambrecht, Nils W., Agrawal, Anshu, Said, Hamid M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842991/
https://ncbi.nlm.nih.gov/pubmed/31369292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00172.2019
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