The Chromatin Remodeler Brg1 Integrates ROS Production and Endothelial-Mesenchymal Transition to Promote Liver Fibrosis in Mice

Trans-differentiation of endothelial cells to myofibroblast contributes to liver fibrosis. Reactive oxygen species (ROS) plays a key role in endothelial-mesenchymal transition (EndMT) although the underlying epigenetic mechanism is unclear. Here we report that endothelial conditional knockout of Brg...

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Publicat a:Front Cell Dev Biol
Autors principals: Li, Zilong, Chen, Baoyu, Dong, Wenhui, Kong, Ming, Shao, Yang, Fan, Zhiwen, Yu, Liming, Wu, Dongmei, Lu, Jun, Guo, Junli, Xu, Yong
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842935/
https://ncbi.nlm.nih.gov/pubmed/31750301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2019.00245
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