Acetaldehyde accelerates HCV-induced impairment of innate immunity by suppressing methylation reactions in liver cells

Alcohol exposure worsens the course and outcomes of hepatitis C virus (HCV) infection. Activation of protective antiviral genes is induced by IFN-α signaling, which is altered in liver cells by either HCV or ethanol exposure. However, the mechanisms of the combined effects of HCV and ethanol metabol...

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Veröffentlicht in:Am J Physiol Gastrointest Liver Physiol
Hauptverfasser: Ganesan, Murali, Zhang, Jinjin, Bronich, Tatiana, Poluektova, Larisa I., Donohue, Terrence M., Tuma, Dean J., Kharbanda, Kusum K., Osna, Natalia A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
Schlagworte:
Liver and Biliary Tract Physiology/Pathophysiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842870/
https://ncbi.nlm.nih.gov/pubmed/26251470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00183.2015
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